A recent study indicates that patients who discontinue popular GLP-1 drugs like semaglutide or tirzepatide tend to recover shed pounds much more quickly than those who end traditional diet and exercise regimens.
Research printed in a leading medical journal points out that while obese individuals often shed about a fifth of their body weight while using the jabs, the weight is regained at an estimated rate of 0.8 kg per month once they quit.
"Individuals buying such drugs need to be informed of the potential of fast weight regain when the treatment ends," cautioned expert Dr. Susan Jebb.
Such speed of recovery means a reversion to original weight within about 18 months.
Weighing Therapies
The research, which reviewed 37 of studies involving over 9,000 of participants, contrasted the effects of these new drugs with older methods.
Scientists note that people who lose weight through dieting typically experience a less rapid weight regain—around 0.1 kg a month—after stopping.
Understanding the Quick Rebound
Doctors believe the mode of action of the injections accounts for the amplified rebound.
GLP-1 drugs imitate a natural hormone called GLP-1, which controls feelings of fullness.
"Artificially providing GLP-1 concentrations far above than the body's typical production could lead to the system to produce less of its own natural GLP-1, and could diminish sensitivity to its actions," noted Dr. Adam Collins, a dietetics expert.
"Discontinuation of this medication results in appetite is no longer kept in check, making overeating a significant risk."
A Lifelong Issue?
Medical guidelines advise the jabs for individuals with weight-linked health risks, accompanied by prescribed diet and exercise modifications.
Many experts contend that, given the high risk of weight regain, the therapy should be considered long-term.
This perspective is reinforced by pharmaceutical companies, who note that the results "highlight the chronic nature of excess weight," comparing it to managing diseases like diabetes.
Patient Experiences
Users who have come off the jabs report a intense resurgence of cravings.
"I experienced a switch flipping and you become ravenous," recalled a patient.
This challenge is worsened if individuals have not established sustainable lifestyle or habit changes during treatment.
Widespread Interest
Survey data show that millions of people in the UK have tried these injections in the past year, with desire being substantial.
- Use is more common among females compared to males.
- The middle-aged age group shows the greatest usage rates.
- Many obtain the drugs through private prescriptions rather than the NHS.
Ultimately, researchers caution that while these medications are effective agents for weight loss, they are not a permanent solution and maintained weight loss hinges on ongoing lifestyle support.
